[1]童雅琴,肖文惠,牟彦竹,等. 牛膝治疗糖尿病周围神经病变的作用机制[J].湖北工业大学学报,2023,(2):44-48.
　TONG Yaqin,XIAO Wenhui,MU Yanzhu,et al. The Mechanisms of Achyranthes Bidentata Blume in Treating Diabetic Peripheral Neuropathy[J].,2023,(2):44-48.
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 牛膝治疗糖尿病周围神经病变的作用机制()
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《湖北工业大学学报》[ISSN:1003-4684/CN:42-1752/Z]

卷:
期数:
2023年第2期
页码:
44-48
栏目:
湖北工业大学学报
出版日期:
2023-04-30

文章信息/Info

Title:
 The Mechanisms of Achyranthes Bidentata Blume in Treating Diabetic Peripheral Neuropathy
文章编号:
1003-4684(2023)02-0044-05
作者:
 童雅琴;  肖文惠;  牟彦竹;  张迎庆
 湖北工业大学生物工程与食品学院， 湖北 武汉 430068
Author(s):
 TONG Yaqin;  XIAO Wenhui;  MU Yanzhu;  ZHANG Yingqing
 School of Biological Engineering and Food, Hubei Univ. of Tech., Wuhan 430068, China
关键词:
 ; 牛膝;  糖尿病周围神经病变;  网络药理学;  分子对接
Keywords:
 ; Achyranthes Bidentata Blume; diabetic peripheral neurpthy; network pharmacology;  molecular docking
分类号:
R285
文献标志码:
A
摘要:
 为探讨中药牛膝治疗糖尿病周围神经病变的机制，分别采用网络药理学及分子对接，对牛膝治疗糖尿病周围神经病变的活性成分进行预测。研究结果表明：网络药理学分析，筛选得到牛膝对糖尿病周围神经病变治疗有效成分11种，关键靶点主要为AKT1 、IL-6、CASP3和 VEGFA。功能富集分析结果表明，牛膝可能通过协同调节HIF-1、MAPK、Fox0等多种生物途径来治疗糖尿病周围神经病变。分子对接结果表明，红厚壳内酯是一种具有良好分子对接性能的先导化合物。本研究阐明了牛膝治疗糖尿病周围神经病变的活性成分和作用机制，为寻找治疗糖尿病周围神经病变的先导化合物和新药研发提供了理论依据。
Abstract:
 To systematically investigate the mechanisms of Achyranthes Bidentata Blume in treating diabetic peripheral neuropathy.Methods: In this study, network pharmacology, molecular docking analysis were used to predict the active components of Achyranthes Bidentata Blume in the treatment of DPN.Results: The network analysis showed that there were 17 active components of Achyranthes Bidentata Blume in treating DPN. And the key targets were AKT1 IL 6, CAPSP3 and VEGFA. The functional enrichment analysis indicated that Achyranthes Bidentata Blume may treat DPN by synergistically regulating many biological pathways, such as HIF 1, MAPK and Fox0 signaling pathway, etc. In addition, the results of molecular docking showed that Inophyllum E might be a promising leading compound with good molecular docking performance. Conclusions: The active components and mechanism of action of diabetic peripheral neuropathy were fully elucidated in this study, and laid a foundation for finding lead compounds of DPN and developing new drugs for the treatment of DPN.

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备注/Memo

备注/Memo:
［收稿日期］ 2021-10-21
［第一作者］ 童雅琴（1998-），女，湖北宜昌人，湖北工业大学硕士研究生，研究方向为药剂学
［通信作者］ 张迎庆（1969-），女，湖北蕲春人，药学博士，湖北工业大学教授，研究方向为天然药物
更新日期/Last Update: 2023-04-26