[1]樊世萌,刘 恋,欧阳敬禹,等. 核壳型磁性分子印迹聚合物制备——以马尿酸为模板[J].湖北工业大学学报,2023,(1):53-58.
　FAN Shimeng,LIU Lian,OUYANG Jingyu,et al. Preparation for Core-shell Magnetic Molecularly Imprinted Polymers Using Hippuric Acid Template[J].,2023,(1):53-58.
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 核壳型磁性分子印迹聚合物制备
——以马尿酸为模板()
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《湖北工业大学学报》[ISSN:1003-4684/CN:42-1752/Z]

卷:
期数:
2023年第1期
页码:
53-58
栏目:
湖北工业大学学报
出版日期:
2023-03-13

文章信息/Info

Title:
 Preparation for Core-shell Magnetic Molecularly Imprinted Polymers Using Hippuric Acid Template
文章编号:
1003-4684(2023)01-0053-06
作者:
 樊世萌1;  刘 恋1;  欧阳敬禹1;  刘 浩1;  尤祥宇1;  李玲玲2;  苏江涛1
 1 湖北工业大学生物工程与食品学院， 湖北 武汉 430068；
 2 武汉文理学院医学院， 湖北 武汉 430345
Author(s):
 FAN Shimeng;  LIU Lian;  OUYANG Jingyu;  LIU Hao;  YOU Xiangyu;  LI Lingling;  SU Jiangtao
 1 School of Biological Engineering and Food, Hubei Univ. of Tech., Wuhan 430068, China;
 2 Medical School , Wuhan Univ. of Arts and Science, Wuhan 430345, China
关键词:
 ; 马尿酸;  尿毒症毒素;  分子印迹;  人血清白蛋白
Keywords:
 ; Hippuric acid;  uremic toxin;  molecular imprinting;  human serum albumin
分类号:
TB383.1
文献标志码:
A
摘要:
 用表面分子印迹技术，以氨基化磁性纳米颗粒为核，以马尿酸（HA）为模板分子、甲基丙烯酸（MAA）为功能单体、偶氮二异丁腈（AIBN）为引发剂、乙二醇二甲基丙烯酸酯（EGDMA）为交联剂，制备核壳型马尿酸磁性分子印迹聚合物（HA-MMIPs）。通过电镜对其结构进行表征，并通过动力学吸附、等温吸附、比较HA-MMIPs与人血清白蛋白（HSA）对HA的吸附等实验，对其性能进行评价。结果表明，HA-MMIPs对HA具有较好的吸附量和印迹效率，在吸附HA上表现出对HSA的明显优势。HA五轮吸附[CD*2/3]洗脱的循环实验表明，HA-MMIPs具有很好的重复再利用能力。这项研究证明HA-MMIPs对马尿酸分子具有良好的分离与吸附能力，对于尿毒症患者体内马尿酸分子的分离与吸附可能存在潜在的优势。
Abstract:
 Using surface molecular imprinting technology, aminated magnetic nanoparticles as the core, hippuric acid (HA) as the template molecule, methacrylic acid (MAA) as the functional monomer, azobisisobutyronitrile (AIBN) as the initiator, and ethyl acetate Glycol dimethacrylate (EGDMA) was used as a crosslinking agent to prepare core-shell hippuric acid magnetic molecularly imprinted polymers (HA-MMIPs). Its structure was characterized by electron microscopy, and its performance was evaluated by experiments such as kinetic adsorption, isothermal adsorption, and comparison of HA-MMIPs and HSA’s adsorption of HA. The results show that HA-MMIPs have better adsorption capacity for HA, better imprinting efficiency, and show obvious advantages over HSA in adsorbing HA; through at least five rounds of adsorption-elution cycle experiments on HA, it is shown that HA- MMIPs have a good ability to reuse. This study proves that HA-MMIPs have good separation and adsorption ability to hippuric acid, and may have potential advantages for the separation and adsorption of hippuric acid in uremia patients.

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备注/Memo

备注/Memo:
［收稿日期］ 2021-08-30
［基金项目］ 国家自然科学基金青年科学基金（81703409）; 湖北省教育厅科学研究计划（B2017047，B2018421）
［第一作者］ 樊世萌（1997- ），女，湖北恩施人，湖北工业大学硕士研究生，研究方向为功能高分子材料
［通信作者］ 尤祥宇（1983- ），男，福建南安人，湖北工业大学讲师，研究方向为功能高分子材料
更新日期/Last Update: 2023-03-14