[1]丁庆林,魏艳红,胡康洪. 数据挖掘鉴定PRIM1与肝细胞癌不良预后相关[J].湖北工业大学学报,2022,(1):71-76.
　DING Qinglin,WEI Yanhong,HU Kanghong. Data Mining Identifies PRIM1 Associated with Poor Prognosis of Hepatocellular Carcinoma[J].,2022,(1):71-76.
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 数据挖掘鉴定PRIM1与肝细胞癌不良预后相关()
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《湖北工业大学学报》[ISSN:1003-4684/CN:42-1752/Z]

卷:
期数:
2022年第1期
页码:
71-76
栏目:
湖北工业大学学报
出版日期:
2022-02-28

文章信息/Info

Title:
 Data Mining Identifies PRIM1 Associated with Poor Prognosis of Hepatocellular Carcinoma
文章编号:
1003-4684(2022)01-0071-06
作者:
 丁庆林;  魏艳红;  胡康洪
 湖北工业大学中德生物医学中心， 湖北 武汉 430068
Author(s):
 DING Qinglin;  WEI Yanhong;  HU Kanghong
 Sino-German Biomedical Center, Hubei Univ. of Tech., Wuhan 430068, China
关键词:
 ; DNA引物酶亚基1;  肝细胞癌;  疾病预后
Keywords:
 ; DNA primase polypeptide 1 (PRIM1);  Liver Hepatocellular Carcinoma (LIHC);  Prognosis
分类号:
R735.7
文献标志码:
A
摘要:
 对DNA引物酶亚基1（DNA primase polypeptide 1, PRIM1）与肝细胞癌 (Liver Hepatocellular Carcinoma，LIHC）不良预后的相关性进行生物信息学研究。作为关键的酶促成分，PRIM1对DNA的合成至关重要。在TIMER数据库中发现，PRIM1在多种癌症中失调，且在LIHC中显著上调，提示其可能参与人类癌症发生发展进程。基因表达综合数据库的LIHC相关数据集以及细胞系和组织证实了PRIM1高表达。经对UALCAN数据库亚组分析，不同种族和亚型的LIHC患者中PRIM1的表达均上调，可辅助判断患者临床病例特征。从cBioPortal数据库中发现PRIM1出现基因组改变，包括拷贝数扩增和意义不明的错义突变和截断突变可能与LIHC发展有关。对PRIM1共表达基因进行基因本体论和京都基因与基因组百科全书富集分析，结果揭示了其涉及的生物学过程和功能。通过Kaplan-Meier Plotter数据库分析PRIM1的预后价值表明，高PRIM1表达与LIHC不良预后显著相关。数据挖掘揭示了PRIM1在LIHC中表达和突变的数据，且与LIHC不良预后相关。
Abstract:
 This research used bioinformatics to study the correlation between DNA primase polypeptide 1 (PRIM1) and poor prognosis of Liver Hepatocellular Carcinoma (LIHC). As a key enzymatic component, PRIM1 is essential for DNA synthesis. It is found in the TIMER database that PRIM1 is dysregulated in a variety of cancers and is significantly up-regulated in LIHC, suggesting that it may participate in the development of human cancer. The high expression of PRIM1 was confirmed in the LIHC-related data set of Gene Expression Omnibus (GEO) database and cell lines and tissues. Subgroup analysis of the UALCAN database shows that the expression of PRIM1 in LIHC patients of different races and subtypes is up-regulated, which can assist in determining the clinical case characteristics of patients. The cBioPortal database found that the genomic changes of PRIM1, including copy number amplification and missense mutations and truncation mutations of unknown significance, may be related to the development of LIHC. The GO and KEGG enrichment analysis of PRIM1 co-expressed genes revealed the biological processes and functions involved. Analysis of the prognostic value of PRIM1 by Kaplan-Meier Plotter database showed that high PRIM1 expression was significantly associated with poor prognosis of LIHC. Data mining revealed the data of PRIM1 expression and mutation in LIHC, and was related to the poor prognosis of LIHC. This study provides evidence for PRIM1 as a potential prognostic marker in LIHC and lays a foundation for further research on the role of PRIM1 in LIHC.

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备注/Memo

备注/Memo:
［收稿日期］ 2021-01-22
［基金项目］ 大学生创新创业训练计划(337203)
［第一作者］ 丁庆林（1993-），男，湖北黄冈人，湖北工业大学硕士研究生，研究方向为肿瘤标志物
［通信作者］ 胡康洪（1964-），男，Regensburg, Germany, 湖北工业大学教授，研究方向为分子病毒学
更新日期/Last Update: 2022-02-25